Cannabis has effective anxiolytic (anti-anxiety) homes, and whilst administered as-wished, can provide alleviation from numerous anxiety problems.
Anxiety, like marijuana, comes with a stigma, but with the increasing impact of anxiety problems on family lifestyles and the economy, it’s no marvel absolutely everyone seems to be looking for a salve.
The courting among hashish and tension disorders exists, however remains absolutely misunderstood. Anxiety offers differently in each patient, and there may be no definitive therapy with conventional capsules, so just believe something as variation because the hashish plant.
Cannabinoids have demonstrated utility in the management of cancer, obesity, and neurologic disease. More recently, their immunosuppressive and anti-inflammatory properties have been identified for the treatment of several dermatologic conditions. This review thus assesses the therapeutic potential of phytocannabinoids, endoocannabinoids, and chemically synthetic cannabinoids in the management of cutaneous disease. The PubMed® and Scopus® databases were subsequently reviewed in December 2017 using MeSH and keywords, such as cannabinoid, THC, dermatitis, pruritus, and skin cancer. The search yielded reports on the therapeutic role of cannabinoids in the management of skin cancer, acne vulgaris, pruritus, atopic and allergic contact dermatitis, and systemic sclerosis. While cannabinoids have exhibited efficacy in the treatment of inflammatory and neoplastic skin conditions, several reports suggest pro-inflammatory and pro-neoplastic properties. Further investigation is necessary to understand the complexities of cannabinoids and their therapeutic potential in dermatology.
While the term “cannabis” often draws association to marijuana, cannabinoids represent a diverse class of hydrophobic compounds, deriving from plants (phytocannabinoids), animals (endocannabinoids), and chemical synthetics (Table 1).1 In mammalian tissue, two G protein-coupled cannabinoid receptors have been identified: cannabinoid receptor 1 (CB1R) in brain and neural cell lines and cannabinoid receptor 2 (CB2R) in the immune system.2,3 The cannabinoid receptors, transporters, and enzymes form the endocannabinoid system (ECS).4 Furthermore, phytocannabinoids, endoocannabinoids, and chemically synthetic cannabinoids bind to the CB1R/CB2R and induce cannabimimetic responses via ECS activation as shown in Figure 1.5
The neuropathic properties of cannabinoids are well established and utilized in the treatment of obesity, cancer, spasticity, and tremor. More recently, the immunosuppressive and antiinflammatory effects of cannabinoids have been investigated in the treatment of inflammatory bowel disease, arthritis, vascular inflammation, and common dermatologic conditions.5-9 Herein, we provide a literature review to assess the therapeutic potential of cannabinoids as it relates to their role in skin growth control and homeostasis, pruritus, inflammation, and fibrosis.
Figure 1: Endocannabinoid system of the skin5
Adapted from figure 1 in Bíró T, et al. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends Pharmacol Sci. 2009 Aug;30(8):411-20. Adapted with permission from the author, Bíró Tamás. License 4456340761996 granted by the Elsevier dated October 26, 2018.
Cannabinoids in Skin Growth Control and Homeostasis
Cannabinoids influence the homeostasis of keratinocytes, melanocytes, and sebocytes through CB1R/CB2R-dependent and -independent mechanisms.1,10,11 In the epidermis, CB1R activity in the stratum spinosum and stratum granulosum and CB2R in the basal layer may increase DNA methylation in human keratinocytes through a p38 MAP kinase to inhibit keratinocyte proliferation.8 In contrast, endocannabinoids inhibit keratinocyte proliferation independently of the CB1R/CB2R potentially through peroxisome proliferator-activated receptor gamma (PPAR-γ) and/or G-protein coupled receptor GPR55 activity.12
Non-Melanoma Skin Cancer (NMSC)
Given their role in keratinocyte homeostasis, cannabinoids influence basal and squamous cell carcinoma development.1 Following long-term exposure to ultraviolet B (UVB) light, tumorigenesis was significantly increased in CB1R/CB2R+/+ mice in comparison to CB1R/CB2R–/– mice, suggesting a receptor-dependent role of UV-induced skin carcinogenesis.13 In contrast, Gegotek et al.14 defended the anti-neoplastic properties of cannabinoids. The authors found a significant reduction in endocannabinoid receptors, anandamide (AEA), and 2-arachidonoylglycerol (2-AG) in keratinocytes and fibroblasts following UVA and UVB radiation. They determined that AEA exhibits nuclear factor kappa B (NFkB) inhibitory activity independently of CB1/CB2R, supporting pro-apoptotic properties of cannabinoids.14
Other reports, in comparison, have supported a CB1/CB2- dependent pathway as anti-neoplastic.15,16 WIN-55,212-2 (a mixed CB1/CB2 agonist) and JWH-133 (a CB2 agonist) decreased the viability of the skin tumor cells in mice with PDV.C57 epidermal tumor cells. The antitumoral activity resulted from an induction of apoptosis and impaired tumor vascularization with decreased expression of vascular endothelial growth factor (VEGF), placental growth factor, and angiopoietin 2.15
The paradoxical findings (i.e., cannabinoids exhibit both pro- and anti-neoplastic properties) may be explained by concentration-dependent effects.1 Nanomolar levels of endogenous cannabinoids associated with UVB and chemical carcinogens may stimulate NMSC tumorigenesis, while micromolar levels of exogenous cannabinoids may decrease NMSC growth. Data supports a similar concentration-dependent effect of cannabinoids on melanoma development.1
Melanoma Skin Cancer
Human melanomas express CB1R/CB2R and activation of these receptors is associated with decreased growth and increased apoptosis in mice.10 In vitro and in vivo, tetrahydrocannabinol (THC) induced autophagy, loss of cell viability, and apoptosis in melanoma A375, SK-MEL-28, and CHL-1 cell lines. Compared to temozolomide, THC and cannabidiol inhibited melanoma viability, proliferation, and tumor growth in mice with BRAF wild-type melanoma xenografts.16
Nonetheless, CB1R activation may promote tumor growth in melanoma. Compared to control, melanoma cells without CB1R showed reduced p-Akt and p-ERK expression, reduced colonyforming ability and cell migration, and increased cell cycle arrest at G1/S.17The influence of cannabinoids in the development of skin cancers is evidently complex. While most reports validate the anti-neoplastic properties of cannabinoids, the evidence remains equivocal.1,10,14-16 Given the immunomodulation properties of cannabinoids, further investigation of its effects on immunosurveillance is imperative to appreciating the principal therapeutic effects.4
Acne Vulgaris
Similarly, the regulatory function of cannabinoids on sebocytes has been implicated in acne vulgaris treatment.11,18,19 Sebocytes positively regulate sebaceous gland lipid homeostasis and negatively regulate sebocyte survival via CB2R.20 Specifically, cannabidiol inhibited the lipogenic actions of arachidonic acid, linoleic acid, and testosterone, and thus decreased sebocyte proliferation and lipogenesis.11 The principal investigator reinforced the sebostatic properties of cannabichromene and THC but noted pro-sebaceous activity of cannabigerol and cannabigerovarin.18 In a single-blinded, split-face study, 3% cannabis seed extract cream decreased skin sebum and erythema content, demonstrating a potential treatment for acne vulgaris and seborrhea.19
Cannabinoids in Pruritus
Activation of CB1R/CB2R in cutaneous nerve fiber bundles may decrease excitation of these nerve fibers and thus attenuate axon reflex flare responsible for the sensation of pruritus.21,22 Utilizing an acute allergic murine model, Schlosburg et al.23 established that systemic THC reduced scratching response induced by compound 48/80. Additional mice were treated with an inhibitor of fatty acid amide hydrolase (FAAH), the principal enzyme responsible for degradation of anandamide, which displayed equivalent scratch-reduction to loratadine and dexamethasone administration. The authors concluded that neuronal FAAH suppression reduces pruritus via CB1R activation, establishing the therapeutic role of cannabinoids in pruritus.23
WIN-55,212-2 has also exhibited anti-pruritic activity in murine models.24 Following intradermal serotonin injection, WIN- 55,212-2 displayed a significant and dose-dependent reduction in pruritus. Notably, reduced levels of monoamines in spinal tissue, secondary to artificial neurotoxic destruction, showed no impact on the anti-pruritic activity of WIN-55,212-2. These findings suggest that cannabinoid’s anti-pruritic properties act distinctly and independently from descending serotonergic and noradrenergic pathways.24
In human skin, peripheral administration of HU210, a cannabinoid receptor agonist, reduced histamine-induced itch in 18 participants.21 HU210 reduced vasodilation and neurogenic flare reaction with decline in neuropeptide (namely CGRP) release. However, co-administration of HU210 and histamine amplified protein extravasation significantly higher than histamine alone.21 Although cannabinoids exhibit predominant anti-pruritic properties, this additional finding indicates a more complex relationship between cannabinoid receptors and histamine.
The endocannabinoid palmitoylethanolamide (PEA) also exhibits anti-pruritic properties when applied topically. In an open-label application of a PEA-containing emollient (PEACE), 14 of 22 patients with prurigo nodularis, lichen simplex, and pruritus had an average itch reduction of 86.4%.25 Similarly, in an observational, prospective cohort study of 2456 patients with atopic dermatitis, the average itch on standard visual analogue scale (VAS) was reduced from 4.89 to 1.97 after 39 days of treatment with PEACE (P < 0.001). While the tolerance was assessed by physicians as very good or good in 66.3% and 25.7% of participants, 3.4% displayed poor tolerance with significant pruritus, burning, erythema, and/or miscellaneous events.26
Hemodialysis patients, likewise, demonstrated improved uremic pruritus following use of topical AEA and PEACE. After twicedaily application, 8 of 21 (38.1%) participants had resolved uremic pruritus as validated by both VAS and questionnaire method.27 Overall, these findings indicate a therapeutic role for cannabinoids in the management of itch but double-blinded, placebo-controlled studies are necessary to further determine their efficacy.8
Cannabinoids in Inflammation and Fibrosis
While pro-inflammatory properties have been identified, cannabinoids exert a largely anti-inflammatory effect by cannabinoid receptor-dependent and -independent mechanisms.5,6In mice modules, WIN-55,212,2 decreased tumor necrosis factor (TNF), interleukin (IL)-12, IL-1β and CXCL8 (IL-8), while THC decreased TNF and IL-6 when coadministered with lipopolysaccharides, but increased these cytokines when co-administered with Legionella pneumophila. Furthermore, cannabinoids suppress T helper type 1 (TH1)-cell immunity and promote TH2-cell immunity through cannabinoid type 2 receptor (CB2R) on B, T, and antigen-presenting cells.6 These potential anti-inflammatory properties have been indicated in the treatment of atopic dermatitis (AD), allergic contact dermatitis (ACD), and systemic sclerosis.
Atopic Dermatitis
Related to their anti-inflammatory and anti-pruritic effects, cannabinoids may function to treat AD.9 CB1R– mice displayed an increased response to fluorescein isothiocyanate-induced atopic-like dermatitis and decreased epidermal barrier repair. Specifically, IL-4, thymic stromal lymphopoietin (TSLP), and CCL8 cytokine were elevated in these mice, suggesting that CB1R maintains epidermal barrier homeostasis and attenuates type 2 CD4+ T helper cell response.28
Clinically, PEACE has demonstrated efficacy in the treatment of AD.26,29,30 In the aforementioned cohort study discussed in the section on pruritus, PEACE not only reduced pruritus but improved dryness, excoriation, lichenification, scaling, and erythema in 70% of patients with AD, as determined by physician assessment. Globally, AD symptoms improved substantially in 56.3% of participants and reduced weekly topical steroid use by 62%.26
In an investigator-blinded, split-body trial of 25 children and 18 adults with AD, Del Rosso29similarly demonstrated the therapeutic value of PEACE. The combination of PEACE and topical corticosteroid resulted in faster AD clearance when compared to moisturizer and topical corticosteroid. Additionally, PEACE prolonged the mean time to flare by 28 days compared to moisturizer.29 A similar split-body trial of 74 participants found that PEACE versus emollient alone prolonged time to AD flare by a median of 43 days and 29 days respectively. Mild stinging and burning was reported by 9 (12.2%) participants.30
In addition to topical application, dietary hempseed oil may improve AD. In a randomized, crossover study, daily consumption of 30 ml hempseed oil decreased skin dryness, itchiness, and use of dermal medications compared to consumption of olive oil. Symptomatic improvement may have resulted from the high concentration of polyunsaturated fatty acids in hempseed oil.31
As evidenced by several clinical studies, PEACE is efficacious in the treatment and further management of AD.26,29,30 Its therapeutic role has been suggested not to replace topical corticosteroids but rather to complement and reduce their use.26,29 Further research is necessary to understand the potentially synergistic mechanism of combination PEACE and topical steroids.
Allergic Contact Dermatitis
The anti-inflammatory properties of cannabinoids may also serve to treat ACD.9Specifically, CB1R/CB2R–/– mice had increased cutaneous contact hypersensitivity induced by 2,4-dintirofluorobenzene (DNFB). Additionally, THC decreased ear swelling and reduced Gr-1+ granulocytes following DNFB administration. Mice deficient in FAAH, furthermore, displayed decreased allergic response. These findings support that CB1R/ CB2R activation reduces inflammation in ACD. A notable exception, acute administration of a CB2R antagonist initially diminished inflammatory response, suggesting that CB2R antagonism may initially reduce acute inflammation but later propagate it.32
Further studies have similarly suggested a pro-inflammatory role of CB2R activation.33,34Following DNFB-induced ACD, mice deficient in CRB2 exhibited decreased ear swelling after 24 hours. Additionally, 2-AG activation of CB2R was associated with increase in ear weight in murine models and elevation of IL-8 and MCP-1 gene expression in human leukemia cell line HL-6.33 Ueda et al.34 further supported the pro-inflammatory activity of CB2R in mice.
Systemic Sclerosis
The therapeutic role of ECS has also been proposed for the management of systemic sclerosis.35,36 Ajulemic acid (AjA), a synthetic analogue of THC, significantly prevented bleomycininduced dermal fibrosis and modestly reduced its progression in three independent murine models. Moreover, co-treatment of AjA and a selective PPAR-γ antagonist entirely reversed the antifibrotic effects, illustrating that AjA activates PPAR-γ to reduce and further prevent fibrosis. Given its tolerated therapeutic dose, AjA offers a potential treatment for systemic sclerosis.37
In a randomized, placebo-controlled, double-blinded phase 2 clinical trial (NCT02465437) of 42 participants with diffuse cutaneous systemic sclerosis, lenabasum (AjA, JBT-101) significantly improved Combined Response Index Systemic Sclerosis (CRISS) scores by 33% in addition to the Modified Rodnan Skin Score, Systemic Sclerosis Skin Symptoms Questionnaire, and Health Assessment Questionnaire Disability Index.38,39 While one participant withdrew from the study due to dizziness, lenabasum established an acceptable safety profile without severe adverse events secondary to the study drug.39
Conclusion
These reports demonstrate the evident but complex role of cannabinoids and the endocannabinoid system in skin homeostasis and pathology. Clinical trials have supported the therapeutic role of cannabinoids in the management of acne vulgaris, pruritus, atopic dermatitis, and systemic sclerosis, as highlighted in Table 2.19,25,26,27,29,30,31,38,39In vitroand in vivo studies have further indicated the potential therapeutic use of cannabinoids in skin cancer and allergic contact dermatitis.10,14,32 While the majority of evidence emphasizes the anti-inflammatory, anti-neoplastic activity of ECS, pro-inflammatory and proneoplastic properties have been documented.13,17,21,32,33,34,36 Further investigation is imperative to understand the influence of the cannabinoid type, delivery method, and concentration on pro- and anti-inflammatory mediators in skin homeostasis to ultimately define the therapeutic role of cannabinoids in clinical dermatology.
Table 2: Clinical studies of cannabinoid use in dermatology. AjA = ajulemic acid; BID = twice daily; CRISS = Combined Response Index in diffuse cutaneous Systemic Sclerosis; HAD-QI = Health Assessment Questionnaire Disability Index; MRSS = Modified Rodnan Skin Score; PEACE = PEA-containing emollient; q = every; QD = once daily; SSc = systemic sclerosis; VAS = Visual Analogue Scale
Sadly, heart attacks are one of the most common injuries in the nation. It has been reported that your body will give warnings signs of a heart attack up to six months before it occurs. Have you experienced any of these symptoms? If so, you may need to schedule an appointment with your health care provider.
In the United States, heart disease is the leading cause of death. It can cause a variety of ailments that affect your heart. Some of these conditions include coronary artery disease, arrhythmia, and congenital heart defects.
You can improve your heart health by improving your diet, exercising, taking iron supplements, and increasing your omega-3 fatty acid intake through food sources or supplements. Meanwhile, watch for the following warning symptoms that your body may be prone to a heart attack.
Cannabidiol (CBD) is a phytocannabinoid, with anti-apoptotic, anti-inflammatory and antioxidant effects and has recently been shown to exert a tissue sparing effect during chronic myocardial ischaemia and reperfusion.
Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.
BACKGROUND AND PURPOSE
Cannabidiol (CBD) is a phytocannabinoid, with anti-apoptotic, anti-inflammatory and antioxidant effects and has recently been shown to exert a tissue sparing effect during chronic myocardial ischaemia and reperfusion (I/R). However, it is not known whether CBD is cardioprotective in the acute phase of I/R injury and the present studies tested this hypothesis.
We have the cardiovascular system to thank for our beating heart and the blood vessels and blood that transport oxygen, nutrients and hormones throughout our body.
On top of that, our cardiovascular system helps regulate our body temperature and the fluids in our body and also protects our body with white blood cells, antibodies and other complement proteins.
As you can imagine, keeping our cardiovascular system running smoothly and in tip-top shape is vital to living a healthy life. We can do that by being active and eating right, but how about by incorporating CBD into our routine?
While we don’t normally think of anxiety as desirable, it’s actually a critical adaptive response that can help us cope with threats to our (or a loved one’s) safety and welfare. These responses help us recognize and avert potential threats; they can also help motivate us to take action to better our situation (work harder, pay bills, improve relationships, etc.). However, when we don’t manage these natural responses effectively, they can become maladaptive and impact our work and relationships. This can lead to clinically diagnosable anxiety-related disorders. We’ve all heard the saying, “stress kills.” It’s true!
Everyone feels anxious from time to time. Anxiety is one of our natural self-defense mechanisms. When anxiety gets out of control, it can impede a person’s ability to lead a normal life. Anxiety disorders are the most common mental health issues in America. It is estimated that more than 40 million Americans are affected by anxiety every year. Many of those people have never treated their anxiety. Instead, they try to deal with it themselves.
There are many treatments available for anxiety disorders. There are pharmaceutical drugs that can be prescribed and there are other treatments available, such as cognitive behavioral therapy. There’s also self-help techniques available, and natural remedies such as Cannabidiol for example.
Bringing another human into this world using your body to create it Is one of the most beautiful things our bodies can do, even if it is a pretty gross process. But not all women can jump into this new role with a perky smile and tons of energy, some women experience postpartum depression, and CBD may be able to help.
Cannabidiol (CBD) has shown in studies to work as an anti-depressant, and may even work faster than common pharmaceuticals. By elevating chemicals that are usually lacking in depressed patients, CBD may be able to help those who are experiencing postpartum depression.
Your brain has around 86 billion neurons. To function as a unit, all of these neurons have to learn to communicate with each other. This happens through the work of neurotransmitters. Neurotransmitters are brain chemicals that carry messages. There are many types of neurotransmitters and each one has its own functions. One of these neurotransmitters is dopamine. Dopamine is regarded as the celebrity among neurotransmitters because of the following:
An appropriate level of dopamine helps you to focus better. You see, dopamine has to be in the proper amounts inside your brain to help to stay alert, focused and able to remember things easily. Whenever you daydream, forget where you put your keys or simply wonder whether you locked the front door when you left home this morning, your dopamine levels in your brain are likely to be depressed (too low).
Adequate dopamine levels provide you with the desire, drive or motivation to get things done. Dopamine also helps to regulate pleasure so when you’re experiencing pleasure dopamine is released and it also causes you to seek out pleasure promoting activities.
People are switching to CBD instead of their prescribed pharmaceuticals. There are several reasons that medical cannabis is more attractive to those suffering from depression like a shorter list of side effects and feeling like it actually works. A study published this month just added another reason to make the switch, and it’s because CBD may be able to work faster than your average pharmaceutical.
Cannabidiol(CBD) may be a valid treatment for depression because of its ability to interact with the brain chemistry involved with the disorder. It also has shown to be able to help with many of the symptoms like anxiety, pain, and fatigue. Current studies believe that inflammation may also be a cause of depression, which cannabidiol has shown it can help reduce. The side effects of CBD are rare and less severe than those of anti-depressants, and it might be able to work faster than commonly prescribed pharmaceuticals.
Do you have a difficult time being motivated to do things? Things like exercising, taking a shower, or keeping your house clean? While being exhausted from work and/or taking care of the family can play a huge role in how you use your energy, depression can make that limited pool of motivation dry up fast. But there are a few things you can do to assist yourself making accomplishment a bit easier.
Why Does Depression Take Away Motivation?
You might be curious as to how depression has anything to do with motivation. Someone who has been struggling for years with depression and knows how it feels to feel like they avoid doing everything and anything may wonder why this happens. Especially when you get labeled as lazy or a slob, it would be nice to know what is going on in the noggin to help explain yourself to people and know what kind of help you need.
Where Does Motivation Come From?
To know how depression impacts motivation, we need to understand how we get motivated in the first place. What gets us out of bed in the morning and drives us to do our daily tasks? The answers lie in your neurotransmitters.
Both dopamine and serotonin play a role in motivation. This is why pharmaceutical antidepressants have been so successful. Of course, there are natural ways to improve your brain function, but not every brain is the same, and some people need a little help. Until recently, pharmaceuticals were the only medication available to help with this chemical imbalance, but now scientists believe CBD can be in the running as well. But to know how any of those even work, you need to know how your brain uses these neurotransmitters to drive your motivation.
Dopamine
Dopamine is one of the neurotransmitters that help create the sense of emotion. The chemical signal gets passed in between brain cells through the synapse where it interacts with various receptors. There are many different pathways dopamine can take, but the one that leads to motivation is the mesolimbic pathway.
The mesolimbic pathway plays a large role in motivation and runs from the middle of the brain and branches out to several places like the cerebral cortex, which has shown in studies to be linked to motivation.
The nucleus accumbens is also affected by the mesolimbic pathway, studies show. This region of the brain triggers feedback to help the brain predict when a reward is coming. Basically, your brain recognizes that something important is about to happen so it kick starts the dopamine production.
Dopamine in this situation is meant to encourage people to perform tasks. People who have more dopamine in their striatum and prefrontal cortex have shown in studies to be more productive. The dopamine levels in the brain are influenced more by the cost and benefit aspect of a task rather than the pleasure of the actual activity. Though you may not enjoy the activity, dopamine makes sure you do it anyway because the reward at the other end is worth it.
Serotonin
Serotonin also plays a role in motivation. This neurotransmitter is what helps make the effort to complete a task less overwhelming. The way it works is by carrying messages between nerve cells, and it does most of its work in your intestines or central nervous system. It plays a regular role in regulating your appetite, sleep schedule, dreams, and mood.
A study found that when volunteers took a medication that increased their serotonin levels, they put more effort toward a task. Studies have also found that an increase in serotonin levels reduced the levels of apathy, making things matter more and easier to complete.
Cannabidiol (CBD) is a natural alternative that has been outshining anti-depressants in the lab as well as in our minds. Often times when we think of depression, the word sad comes to mind. but it is so much more than that. Depression is more than just feeling sad, it’s feeling empty, incomplete, worthless, hopeless, and all the other less’s you can think of.
Finally, we have discovered a medicine that helps with your depression and doesn’t change who you are, doesn’t have worse off side-effects, and isn’t a million dollars.
Over 16 million Americans suffer from major depression each year. It is one of the most common disorders that plague this planet. We hear about it often, but what do we really know about it?
What Is Depression?
Depression isn’t an emotion, it is a condition. It is more than just being sad and moping around, though there is plenty of that.
Symptoms of Depression
Excessive hunger or loss of appetite
Loss of interest in activities you once enjoyed
Early to wake up or trouble falling asleep
Mood swings, including sadness
Feelings of hopelessness, guilt, apathy, and anxiety
Excessive crying, agitation, irritability or isolation
Hard to concentrate and slow moving
Thoughts of suicide
Depression is a whole new world of discomfort that many of us have to face every day. Considering the symptoms, it can be very difficult to escape this reality your brain has created. And the best part about depression is that it comes in many different flavors.
Different Types of Depression
Major Depressive Disorder
Symptoms of depression happen every single day for at least two weeks straight
Can be resolved within months with correct treatment
Persistent Depressive Disorder
Experience the symptoms of depression for most days for at least two years
Generally doesn’t reach the severity of major depressive episodes
Post-Partum Depression
Having depression symptoms after having a baby for at least two weeks but can last up to a year
10-20% of mothers experience Post-Partum Depression
Premenstrual Dysphoric Disorder
Having severe symptoms of depression a week before your menstrual cycle
The symptoms are so severe that they impact the day to day life in a big way like being unable to eat or having emotional episodes
Seasonal Affective Disorder
Depression that comes and goes with the varying levels of sunlight in the fall and winter but not during the spring and summer
Can be resolved in a few months with correct treatment
Depression Treatment
Living with depression is literally fatal. You can find yourself at the edge and ready to jump off to escape the nothingness that surrounds you.
Luckily, you are not alone. New research is constantly coming out to help you and your condition, people are finding tips and tricks to cope with your everyday life, and this lonely disease doesn’t have to be so isolated anymore.
But what about when the kind words aren’t enough? What happens when the uplifting twitter posts and helpful blog posts aren’t helping?
Medication in the mental health world can be so very tricky. Even though with new studies relating genetics to anti-depressants, it is still trial and error when finding the right medication.
This would be fine if side effects weren’t things like “gaining weight” and “loss of sexual desire” and “suicidal thoughts”. Things people with depression really don’t need on their plate. This why many people are turning to a safe and more natural alternative, Cannabidiol (CBD).>
Why CBD for Your Depression
If you have depression, you’re tired. Not only from the exhausting day to day life of staying alive, but finding a cure to this disease that has taken control over your life. Maybe you’re on your 6th medication that the doctor has prescribed, maybe you’re on your first, maybe it’s not working. Maybe it’s time to try something new.
CBD is a chemical found in the cannabis plant that has no psychoactive properties but all the good health benefits of cannabis. It interacts with what is called the endocannabinoid system. This system is the regulator of your body, telling it how to behave. This includes regulating your mood and emotional behavior.
In a study that put animal test subjects under stressful situations, they found that CBD has anti-depressant and anti-anxiety effects. Researchers have even suggested that CBD could be a replacement treatment for depression with its ability to quickly reduce symptoms of depression. They have found that the mental effects of CBD can be almost immediate.
That sounds like something someone at the end of their rope can get on board with, right?
Not only do you get your results quickly and safely, they don’t change you. One of the most common complaints about conventional anti-depressants is they make your emotions dull, making you dull. Another complaint is the inability to quit the drug they are prescribed, having to wean themselves off while paying buckets and buckets of money for a pill they are trying to get rid of.
You can quit CBD in one day after months of taking the medication and not have serious physical withdrawals that can send you to the hospital. You won't be itching for some more and it isn’t something you need to invest in for the rest of your life because you are someone who believes in conquering their disorder. And some pills aren’t going to be the thing that holds you back.
If you are ready for a new path that could lead to a healthier you, check out our shop today and find the remedy that suits you best.
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If you’ve ever experienced depression, you may be familiar with the incredible weight that chains itself toy our chest making getting out of bed a huge accomplishment for the entire day. But what about those days where you just can’t? Is there any self-care ideas that you can do from your bed to get you started for the day and feeling good enough to pull the covers off?
Many people are talking to their doctors about switching over from pharmaceuticals to CBD hemp oil for depression. But because of how new this type of treatment is for many people, it can be a little overwhelming to get started. So if you’re here trying to figure out how to take CBD oil for depression, you’ve come to the right place.
Have you fallen into a rut of sadness where nothing you do brings you joy? You might not have other symptoms of depression, but for some reason nothing is satisfying. You may have developed melancholic depression, and CBD oil may be able to help.
CBD oil has shown in studies to be effective in reducing symptoms of depression, including symptoms that also occur in melancholic depression. By elevating chemicals that are usually lacking, elevating chemicals that offer a boosted mood, and elevating chemicals that promote neurogenesis, CBD oil may be a valid treatment for melancholic depression.
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